Our newest protocol, the Sleep Protocol is now available! Find out more here.


The Zelenko Protocol

A study from July 2020 shows a simple and safe protocol for combating Sars-Cov-2 that decreased the rate of hospitalization by 84% and 5 times less all-cause death in high-risk patients.

In this article, you’ll learn about the structure and results of the Zelenko Protocolstudy to treat outpatients with early diagnosed Sars-Cov-2. We’ll introduce you to the physician who led the study and, most importantly, we’ll line out how to implement the protocol so you can take ownership of your health and response to Sars-Cov-2. 

The Zelenko Protocol Study: 

In July of 2020, an important, peer-reviewed article was published in the International Journal of Antimicrobial Agents. The study that this paper discusses should have gotten more media coverage, as it presents strong evidence for some simple steps that can be taken to dramatically improve outcomes for at-risk individuals who test positive for Covid-19. Here at True Protocols, we believe that true health and true science should be accessible to all, so let's take a look at some features of this study and how the protocol can help empower you to take action and defend yourself from serious illness resulting from Covid-19.

The Zelenko Protocol is a triple therapy intended to combat Covid-19. It is made up of low doses of zinc sulfate, hydroxychloroquine (HCQ), and azithromycin, administered over the course of five consecutive days. In the initial study, 141 patients, all of whom tested positive for the Sars-Cov-2 virus, were prescribed the Zelenko Triple Therapy. All 141 participants were of a moderate-to-severe risk category, meaning they were either over the age of 45, or they were positively tested to have one or more known comorbidities. 335 patients tested positive for Covid-19, but 208 of the 335 patients did not meet the risk stratification criteria and so were not treated. 

It’s important to recognize the impacts of this study because many of the statistics we’re presented within the media are difficult to decipher. Being a risk-stratified study (focusing only on those patients who are most at risk) makes the results of the treatment even more striking. 

After four days of the onset of symptoms, the selected 141 patients got a prescription for the triple therapy for five days. Independent public reference data from 377 confirmed COVID-19 patients of the same community were used as the untreated control. 

The results? 

Four out of 141 treated patients (2.8%) were hospitalized compared to 58 of 377 untreated patients (15.4%). This means theodds of hospitalization of treated patients were 84% less than in the untreated group.

One patient (0.7%) died in the treatment group versus 13 patients (3.5%) in the untreated group.The treated patients were five times less likely to die from all-cause mortality.

Not only are these results significant, but there were no reported cardiac side effects.Zinc(an essential mineral with well-established antiviral effects), HCQ (antiviral), and azithromycin (antibiotic) each have a long history and accepted safety profiles. The low dosages of the Zelenko Protocol are a conservative risk, especially in contrast to the apparently powerful benefits. 

Who is Dr. Vladimir Zelenko? 

Dr. Zelenko graduated summa cum laude with a B.A. degree with high honors in Chemistry from Hofstra University. After receiving an academic scholarship to attend S.U.N.Y. at Buffalo School of Medicine, he earned his M.D. degree in May 2000. Dr. Zelenko completed his family medicine residency at South Nassau Communities Hospital in Oceanside, N.Y. in May 2004. Since then, Dr. Zelenko has practiced family medicine in New York’s Hudson Valley.

He’s been described by many of his patients as a family member, and is a medical adviser to the volunteer ambulance corps in Kiryas Joel, New York. In March 2020, Dr. Zelenko’s team was one of the first in the country to successfully treat thousands of Covid-19 patients in the prehospital setting.

Dr. Zelenko developed the “Zelenko Protocol” and his work has earned over 100 citations in top peer-reviewed journals. He has been nominated for the Presidential Medal of Freedom, and the Nobel Peace Prize. 

How to implement the Zelenko Protocol

According to Dr. Zelenko, it’s important to start the triple therapy as early as possible after the onset of symptoms, because SARS-CoV-2 viral load seems to peak at day five to six after symptom onset. Severe cases progress to acute respiratory distress syndrome (ARDS) after only eight to nine days.

Because of this advantage of early treatment, Dr. Zelenko recommends a “Prophylaxis” approach. Prophylaxis is an action taken to prevent or protect against a specified disease. In a nutshell, it means being prepared in advance for when you’re exposed to Covid-19. 

As zinc deficiency may play an important role during infection, development, and the clinical course of COVID-19, zinc supplementation in accordance with defined recommended dietary allowances should be evaluated as a simple option for primary prevention. Zinc has a high safety margin and it would be physiologically already available if, for example, treatment with HCQ is initiated.

His recommendations for prophylaxis vary according to your level of risk. His advice is as follows: 

Low-Risk Patients

“Young healthy people do not need prophylaxis against Covid 19. In young and healthy people, this infection causes mild cold-like symptoms. It is advantageous for these patients to be exposed to Covid-19, build up their antibodies, and have their immune system clear the virus. This will facilitate the development of herd immunity and help prevent future Covid-19 pandemics. However, if these patients desire prophylaxis against Covid-19, then they should take the protocol noted below.”

Moderate Risk Patients

“Patients from this category are healthy but have high potential viral-load exposure. This group includes medical personnel, caregivers of high-risk patients, people who use public transportation, first responders, and other essential personnel who are crucial to the continued functioning of society. These patients should be encouraged to take prophylaxis against Covid-19 in accordance with the protocol noted below.”

Protocol for Low and Moderate Risk Patients:

Elemental Zinc 25mg once per day

Vitamin D 5000iu once per day

Vitamin C 1000mg once per day

Quercetin 500mg once per day

High-Risk Patients

“Patients are considered high risk if they are over the age of 45, or if they are younger than 45 but they have comorbidities, that is, they have other health conditions that put them at risk. These patients have between a 5-10% mortality rate if they are infected with Covid-19. These patients should be strongly encouraged to take prophylaxis against Covid-19 in accordance with the protocol noted below.”

Protocol for High-Risk Patients:

Elemental Zinc 25mg once per day

Vitamin D 5000iu once per day

Hydroxychloroquine (HCQ) 200mg once per day for 5 days, then once per week

If HCQ is unavailable, then use the Protocol for Low and Moderate Risk Patients as stated above.

If you’re interested in implementing the Zelenko Protocol as a prophylaxis against Covid-19, a great start would be ourImmune Protocol+ which contains an effective balance of Zinc, Vitamin D, and Quercetin. In addition to these recommended supplements, our Immune Protocol+ has the added synergistic benefits ofbromelain, selenium, magnesium, and vitamins A, and K2.