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Announcing Our Newest Addition To The True Protocols Family - Neuro Calm

Our newest supplement, Neuro Calm, is now available for purchase on our website (here).

To narrow it down to one sentence.... Neuro Calm has been specifically designed to temporarily promote relaxation, support cognitive health and/or brain function, aid in energy metabolism and in tissue formation.

That sounds very fancy, but what is it going to do for me?

The Neuro Calm formula was designed to be taken during the day to promote a calm, relaxed mental state, without causing undesirable drowsiness that leads to impaired focus and productivity. Neuro Calm’s combination of herbal components, essential amino acids, and vitamins provides many of the building blocks we already find in our nervous system that send out signals promoting relaxation and alpha brain waves (electrical brain wave patterns associated with a wakeful, but meditative state).

What makes Neuro Calm Different?

While some of the ingredients in this formula are commonly used in sleep-enhancing formulas, those ingredients have been dosed lower here so that their effects are not overpowering. This allows for lower doses to be used (1, maybe 2 capsules) to alleviate anxiety and stress, while higher doses (2-4 caps) could be used to promote sleep onset.

The effects on drowsiness will not be consistent across the board; some people may report drowsiness on a low dose, while others may not report it at any dose and may only experience its calming effects. 

Will Neuro Calm be part of a Protocol?

We created Nuero Calm to be part of our Brain Protocol. This protocol will include a product called Vital Mind, which is currently in production, and we expect it to be available within a few months. As a part of the Brain Protocol, Neuro Calm provides the Yang to the Yin of Vital Mind. While Vital Mind provides the building blocks for all of your major wakefulness neurotransmitters (Dopamine, serotonin, and acetylcholine), Neuro Calm provides that contrasting support for the calming neurotransmitters (Glycine, GABA). 

These supplements can be safely taken together or separately. In line with our desire to create health protocols that help people solve specific health issues, our Brain Protocol and Brain Protocol+ (which will include Magnesium Balance), will help with a variety of different problems related to brain and nervous system health.

Where can I find out more about this supplement?

If you visit the Neuro Calm product page, there is some information about the product. We're in the process of creating a product sheet which will contain more in-depth information about the supplement and its ingredients, but in the meantime you can read more about the ingredients and their effects in this post. If the following is too in-depth you can stop reading here, or come back to the rest of this post at a later date.

L-Theanine

Introduction

L-theanine (LT), an amino acid found in green tea, is commonly used for its calming and relaxing properties. Because of these effects it is commonly used to reduce nervous tension and anxiety. The structure of LT is similar to the excitatory neurotransmitter glutamate, and as such it weakly binds the same receptors as glutamate, inhibiting the binding of glutamate and its subsequent excitatory effects in the central nervous system. 

Benefits

Sources

LT was first found in Camellia sinensis (green tea) in 1949 and makes up 1% of the leaves dry weight. Due to the low availability of LT in green tea many supplements use synthetic LT. For comparison, it has been found that up to 24 mg of LT have been found in single black tea bags.

Contraindications

The FDA recognizes LT to be GRAS (generally recognized as safe). 

There is a theoretical contraindication for the use of LT in hypotensive subjects due its anti-hypertensive properties, however no studies have been done to illustrate this effect.

GABA

Introduction

Gamma-aminobutyric acid GABA) is an inhibitory neurotransmitter that acts on neurons in the central nervous system. This molecule is produced endogenously from glutamate, and interestingly acts antagonistically to glutamate (which is the CNS’ main excitatory neurotransmitter). GABA levels in the brain are directly correlated with an individual’s level of anxiety; higher levels of GABA correlate with lower levels of anxiety and brain waves indicative of a calm, meditative, or pre-sleep state. While it remains to be determined if GABA can pass the blood brain barrier (the research is not clear and scientists can’t decide), it has been considered that orally administered GABA may exert its beneficial effects by acting on the peripheral nervous system through the gut-brain axis. GABA receptors in the CNS are common target sites for many drug classes (such as barbiturates and benzodiazepines) commonly prescribed for anxiety and other neurologic disorders.

Benefits

Sources

High levels of GABA are found in fermented foods. As such, many GABA supplements are made from lactic acid fermentation.

Contraindications

There have been no contraindications identified for the oral supplementation of GABA. Take caution and consult your healthcare professional if you are taking any drugs that act on GABAergic receptors (barbiturates, benzodiazepines).

Glycine

Introduction

Glycine is considered a non-essential amino acid and is one of the primary inhibitory neurotransmitters in the brain. It acts on glycine receptors and is also a co-agonist at NMDA receptors. Glycine is an essential building block for many important endogenous molecules such as glutathione, creatine, bile salts, and purines (a component of genetic material).

Benefits

Sources

Any protein sources.

Contraindications

There are no identified contraindications when taken orally. High daily doses of glycine, up to 30 g/day, have been shown to be practical and safe. Neuro Calm contains nowhere near any toxic dose of glycine. 

Bacopa Monnieri

Introduction

Bacopa monnieri (Bacopa) is a perennial herb commonly found in Australia and India and has long been used in Ayurvedic medicine. It has been gaining popularity in the western world for its cognitive enhancing effects as of late and has extensive research illustrating these benefits.

Benefits 

Sources

Perennial plant commonly growing as a weed in rice fields, found most commonly in India and Australia.

Contraindications

Though there have been no long-term use studies on Bacopa, it appears to exhibit low toxicity in model organisms and humans. Bacopa has a long history of use and is typically well tolerated. One study using a concentrated extract reported gastrointestinal side effects, and was theorized that they may have been caused by its cholinergic effects. As such, caution should be taken when using alongside cholinergic medications. No other detrimental effects were reported in a clinical study in which participants took a daily dose of 300 mg.

Vitamin B6

Introduction

Vitamin B6, also known as pyridoxal-5-phosphate is a water soluble vitamin important to many enzymatic processes, including but not limited to metabolism of homocysteine, and the production of serotonin from 5-HTP, dopamine from tyrosine, and GABA from glutamate. B6 supplementation has been shown to be useful in treating a number of conditions in which affected individuals have a higher incidence of B6 deficiency.

Benefits 

Sources

Vitamin B6 is found in a variety of foods, including brewer’s yeast, sunflower seeds, wheat germ, walnuts, fish, potatoes, and rice. Supplements come in the form of pyridoxal-5-P or pyridoxine HCl. P5P is the active form and is absorbed faster, however it is unclear which form has a higher bioavailability.

Contraindications

Toxicity of high dose supplementation of vitamin B6 has been seen at levels ranging from 500 mg-5 g over a span of months to years. Symptoms of excess supplementation include sensory neuropathies in the extremities that are usually reversible upon continuation. The levels required to reach toxicity is so much higher than that recommended that it is considered to be generally safe for consumption.

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